Nicotinic acetylcholine receptor

structure and function
  • 489 Pages
  • 2.91 MB
  • 6692 Downloads
  • English
by
Springer-Verlag , Berlin, New York
Acetylcholine -- Receptors -- Congresses., Nicotinic receptors -- Congresses., Receptors, Cholinergic -- congresses., Receptors, Nicotinic -- congre
Statementedited by Alfred Maelicke.
SeriesNATO ASI series., vol. 3
ContributionsMaelicke, Alfred.
Classifications
LC ClassificationsQP364.7 .N36 1986
The Physical Object
Paginationxxviii, 489 p. :
ID Numbers
Open LibraryOL2733778M
ISBN 100387171681
LC Control Number86028047

This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases.

Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory. The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience.

Involved in muscle contraction and a Nicotinic acetylcholine receptor book variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, Cited by: This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases.

Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related Author: Akinori Akaike, Shun Shimohama, Yoshimi Misu. Nicotinic Acetylcholine Receptor. Nicotinic acetylcholine receptors (AChRs) are members of the Cys-loop ligand-gated ion channel superfamily including the type 3 serotonin (5-HT), type A and C γ-aminobutyric acid (GABA), and glycine receptors (reviewed in Arias, ; Sine and Engel, ; Albuquerque et al., ).

The nicotinic acetylcholine receptor is a transmembrane allosteric protein that mediates transduction of chemoelectric signals throughout the nervous system by opening an intrinsic ionic channel. This rapid pore opening enables flow of Na +, K +, and, in several. The nicotinic acetylcholine receptor (nAChR) is a typical ion channel type receptor.

nAChR agonists such as Nicotinic acetylcholine receptor book evoke rapid excitatory responses in order of milliseconds. In addition to acute responses, sustained stimulation of nAChRs induces delayed cellular responses leading to neuroprotection via intracellular signal pathways probably triggered by Ca2+ influx.

The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites.

Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide.

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain Eric A. Barnard, David M. Beeson, Victor B. Cockcroft, Mark G Darlison, Andrew A. Hicks, F. Anthony Lai et al.

Pages Insect pest control has continuously evolved from inorganics to botanicals, to chlo­ rinated hydrocarbons, to organophosphorus compounds and methylcarbamates, then synthetic pyrethroids and most recently synthetic nicotinoids as the major classes.

These insecticides allowed high standards of crop protection at minimal cost.

Download Nicotinic acetylcholine receptor FB2

A limitation in each new class of compounds is the selection of. cAMP-Dependent Phosphorylation of the Nicotinic Acetylcholine Receptor: Characterization of the Protein Kinase in Torpedo Electric Organ, Lack of Correlation in Myotubes between Increased Intracellular Levels of cAMP and Influx of Monovalent Ions, Block of Influx by Forskolin Independently of cAMP Levels.

Pages Heilbronn, E. (et al.). Nicotinic Acetylcholine Receptor Technologies guides readers through molecular techniques and behavioral tests used to investigate nicotinic drugs, chronoamperometry, emerging technologies and methods for the analysis of nAChRs, single nucleotide polymorphism (SNP), fluorescence techniques, spectral confocal, allosteric modulators of a7-nAChRs.

Nicotinic acetylcholine receptors (nAChRs) belong to the “Cys-loop” superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors. This book will. Paperback. Condition: New. Language: English. Brand new Book. The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors.

This area of research received great impetus from the identification of the first subunit sequences to. The nicotinic acetylcholine receptor (nAChR) is a typical ion channel type receptor. nAChR agonists such as nicotine evoke rapid excitatory responses in order of milliseconds.

In addition to acute responses, sustained stimulation of nAChRs induces delayed cellular responses leading to neuroprotectio. Duga S, Asselta R, Bonati MT, Malcovati M, Dalprà L, Oldani A, Zucconi M, Ferini-Strambi L, Tenchini ML.

() Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene (CHRNB2) in a representative cohort of Italian probands affected by autosomal dominant nocturnal frontal lobe epilepsy.

Epilepsia, 43 (4): Other articles where Nicotinic acetylcholine receptor is discussed: ion channel: Toxins and disease: several other organisms; the irreversible nicotinic acetylcholine receptor antagonist alpha-bungarotoxin, from the venom of snakes in the genus Bungarus (kraits); and plant-derived alkaloids, such as strychnine and d-tubocurarine, which inhibit the activation of ion channels that are opened.

Identification of Amino Acids of the Torpedo Nicotinic Acetylcholine Receptor Contributing to the Binding Site for the Noncompetitive Antagonist [ 3 H]Tetracaine. Molecular Pharmacology. Nicotinic Acetylcholine Receptor Signaling in Neuroprotection: Medicine & Health Science Books @   Nicotinic acetylcholine receptors (nAChRs) are numerous, diverse, and composed of different subunits forming multiple subtypes.

Nicotinic acetylcholine receptors belong to the Cys‐loop superfamily of receptors that include GABA A, glycine, and serotonin 5HT 3. Each receptor is composed of five individual subunits that assemble together to. Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases.

Biochem Pharmacol ; – CAS Article Google Scholar 9. Lindstrom J, Cited by: Acetylcholine is a chemical that helps muscles contract. It acts as a messenger between nerves and muscles.

People who have myasthenia gravis (MG) often make an abnormal protein called acetylcholine receptor antibody.

This protein interferes with how acetylcholine works.

Description Nicotinic acetylcholine receptor EPUB

At first, this causes muscle weakness in the eye. The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination.

Homology modeling followed by molecular docking and molecular dynamics (MD) simulations. Nicotine is a chemical with multiple biological and neurological actions.

It is a natural alkaloid that mimics the effects of acetylcholine as a neurotransmitter. Nicotinic acetylcholine receptors are cholinergic receptors that activate ligand-gated ion channels in the plasma membranes of certain neurons and muscle cells.

These ion channels are opened by the binding of nicotine. The chapter briefly covers the history of protein and peptide neurotoxins in research on nicotinic acetylcholine receptors (nAChR). It all started with a great help of α-bungarotoxin and other similar α-neurotoxins from snake venoms in isolation from the Torpedo ray electric organ of the muscle-type nAChR as a first individual membrane receptor.

Details Nicotinic acetylcholine receptor PDF

The next contribution of α-neurotoxins was. This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases.

Accumulating evidence suggests that nAChRs in the CNS play import. Nicotinic acetylcholine receptors in health and disease. Molecular Neurobiology15 (2), DOI: /BF Hugo R Arias.

Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain Research Reviews25 (2), DOI: /S(97) Get this from a library. The nicotinic acetylcholine receptor: current views and future trends. [Francisco J Barrantes;] -- This book covers, in a well-organized and comprehensive manner, one of the fasted growing fields in the Molecular Neurosciences - that of the ligand-gated ion channels (LGIC).

Future trends, analyzed. Alcohol and nicotine are often co-abused. As many as 80–95% of alcoholics are also smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco smoke, may functionally interact in the central nervous system and/or share a common mechanism of action.

While nicotine initiates dependence by binding to and activating neuronal nicotinic acetylcholine receptors. Acetylcholine Nicotinic Receptors. Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials.

Each receptor is composed of pentameric combinations of subunits (α, β, δ, ε and γ). Nicotinic receptors are generally divided into three functional classes: muscle subunits (α1, β1, δ, ε, γ. search for books and compare prices.

Words in title. Author. ISBN: OCLC Number: Description: xxxi, pages: illustrations ; 24 cm: Contents: Sect. 1. Introduction to neuronal nicotinic receptors --The history of the neuronal nicotinic receptors --Distribution of cholinergic neurons in the mammalian brain with special reference to their relationship with neuronal nicotinic acetylcholine receptors --Sect.

2. Changeux et al. recently suggested that the SARS-CoV-2 spike (S) protein may interact with nicotinic acetylcholine receptors (nAChRs). Such interactions may be involved in pathology and infectivity. Here, we use molecular simulations of validated atomically detailed structures of nAChRs, and of the S protein, to investigate this "nicotinic hypothesis".Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders.

The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(−) and β2(+)α3(−) interfaces, and a β2(+)β2(−) interface.